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KMID : 0811720030070000183
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Korean Journal of Physiology & Pharmacology
2003 Volume.7 No. 0 p.183 ~ p.0
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Activation of Extracellular Signal-Regulated Kinase in Rat Vestibular Nuclei by Acute Hemorrhage
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Kim Min-Sun
Choi Myoung-Ae
Choi Dong-Wook
Park Jong-Il
Song Jin-Ho
Lee Han-Saem
Kim Kwang-Yong
Park Byung-Rim
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Abstract
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The purpose of this study was to evaluate expression of phosphorylated signal-regulated kinase (p-ERK), which is one of major regulatory factors for transcription of cfos oncogene in neuron, were investigated in the vestibular nuclei of Sprague-Dawley rats following acute hemorrahge. Transient acute arterial hypotension was induced by rapid hemorrhage from the femoral artery under anesthetic condition. Unilateral or bilateral chemical labyrinthectomies was performed 14 days before the start of the experiment to eliminate afferent signals from the peripheral vestibular receptors in the inner ear. The significant number of p-ERK immunoreactive neurons appeared in the caudal aspect of the medial and inferior vestibular nuclei bilataerally following acute arterial hypotension. However, no labeling of p-ERK in the superior and lateral vestibular nuclei was noted. The peak expression of p-ERK in these nuclei was occurred within 5 min after hemorrhage. In unilaterally or bilaterally labyrinthectomized rats, the number of p-ERK immunoreactive neurons reduced completely in the vestibular nuclei. These results suggest that afferent signals from the peripheral vestibular receptors are required for activation of extracellular signal-regulated kinase in the vestibular nuclei following acute hypotension (Supported by Brain Science Research M1-0108-00-0001).
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KEYWORD
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Vestibular nucleus, Hypotension, Signal-regulated kinase
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